Modeling of in vitro drug release from polymeric microparticle carriers

Incorporation of active substances in polymeric microparticles (microencapsulation) is an important technological strategy used the pharmaceutical industry to improve functionality, quality, safety and/or therapeutic efficiency preparations for different routes administration. The current focus research this field on encapsulation small molecules and macromolecules into based biocompatible synthetic polymers biopolymers, such as polypeptides polysaccharides, order achieve preferable drug release kinetics many other advantages. Diversity structure size microparticles, choice polymers, manufacturing processes, allows designing a multitude microcarriers (e.g., monolithic matrix microspheres, hollow microcapsules, water-or oil-core stimulus-sensitive microcapsules), whereby their impact biopharmaceutical profile drugs can be manipulated. results so far indicate that vitro evaluation one key aspects microparticle-type carrier characterization, where application mathematical analysis (modeling) profiles tool elucidating mechanisms, well evaluating influence optimization formulation process parameters microencapsulation procedure. article reviews representative studies which modeling experimentally obtained data was performed microencapsulated model with physicochemical properties, relevance potential limitations approach.